https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index en-au 5 A Saturated Map of Common Genetic Variants Associated with Human Height https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:50431 Wed 28 Aug 2024 15:49:50 AEST ]]> Associations of autozygosity with a broad range of human phenotypes https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:45256 1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.]]> Wed 26 Oct 2022 20:06:39 AEDT ]]> Genetic effects on the timing of parturition and links to fetal birth weight https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:52463 Wed 11 Oct 2023 15:07:44 AEDT ]]> Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:49007 Wed 03 May 2023 12:17:36 AEST ]]> A Multi-Layer Functional Genomic Analysis to Understand Noncoding Genetic Variation in Lipids https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:50411 Tue 25 Jul 2023 17:30:33 AEST ]]> Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53302 0.9). We observed the strongest evidence to date for OPRM1: lead SNP rs9478500 (p = 2.56 × 10–9). Gene-based analyses identified novel genome-wide significant associations with PPP6C and FURIN. Variants within these loci appear to be pleiotropic for addiction and related traits.]]> Tue 21 Nov 2023 12:03:34 AEDT ]]> The power of genetic diversity in genome-wide association studies of lipids https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:48599 Tue 04 Apr 2023 19:22:25 AEST ]]> Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53055 Fri 17 Nov 2023 11:47:02 AEDT ]]>